APAGARD · 12 products
APAGARD nano-hydroxyapatite toothpaste from Japan
Five formulas, one active ingredient. Pick by how concentrated you want it and how much you brush.

Three APAGARD tubes to start with
APAGARD M-Plus Mild Mint, Single Tube
M-Plus, the classic tube: 125 g, mild mint.
Check price on AmazonAPAGARD Premio Double Mint, 100 g
Premio, the concentrated one, in double mint.
Check price on AmazonThe whole range
Twelve tubes and multipacks across five formulas: M-Plus for every day, Premio and Royal for a higher concentration, Renamel for home care between clinic visits, and the stain-removal tubes for coffee, tea, wine and tobacco marks. Sizes run from 100 to 135 grams, in single tubes and packs of two or three.
APAGARD Royal Toothpaste, 135 g
The richest nano-hydroxyapatite paste in the range, 135 g.
- 4.8 oz, 135 g
- Highest nano mHAP content in the APAGARD series
- Twice the nano mHAP of the standard tube
- Liquid conchiolin, a pearl ingredient
- Minimal or zero abrasives
APAGARD Premio Double Mint, Two Tubes
Two tubes of the Premio paste in double mint flavour.
- 105 g, 3.7 oz
- Pack of 2
- Double Mint flavour
- Sangi's nano-hydroxyapatite (nano-mHAP)
- No fluoride
- Part number 4987643122183
APAGARD M-Plus Mild Mint, Two Tubes
Two tubes of the classic M-Plus paste, mild mint.
- 125 g, 4.4 oz
- Pack of 2
- Mild Mint flavour
- Standard, longest-selling version of the range
- No fluoride
- Part number 4987643504002
APAGARD M-Plus Mild Mint, Single Tube
One 125 g tube of the classic M-Plus paste.
- 125 g, 4.4 oz
- Pack of 1
- Mild Mint flavour
- Standard, longest-selling version of the range
- No fluoride
- Part number 4987643501049
APAGARD Premio Brightening, Three Tubes
Three tubes of the higher-strength Premio paste, 105 g each.
- 105 g, 3.7 oz
- Set of 3
- Sangi's nano-hydroxyapatite (nano-mHAP)
- 2023 version
- Nano hydroxyapatite high blending
APAGARD M-Plus Mild Mint, Three Tubes
Three tubes of the classic mild mint M-Plus paste.
- 125 g, 4.4 oz
- Pack of 3
- Mild Mint flavour
- Standard, longest-selling version of the range
- No fluoride
- Part number 4987643504101
APAGARD Renamel Home Care, 120 g
Home-care paste with the maximum nano mHAP level, 120 g.
- 120 g, 4.2 ounce
- Maximum levels of nano mHAP in the range
- Also contains xylitol, PEG and PVP
- Intended for home use between clinic visits
- Suitable for orthodontic brace wearers
APAGARD M-Plus 130 g, Single Pack
A 130 g tube of the classic mild mint M-Plus paste.
- 130 g, 4.58 oz
- Single pack
- Mild Mint flavour
- Nano-hydroxyapatite first synthesised by Sangi in 1978
- Without fluoride
- Unit count 1
APAGARD Smokin' Stain Removal, 100 g
Stain-removal paste for tobacco, tea, coffee and wine marks.
- 100 g, 3.5 oz
- Stain-removal type
- Non-abrasive formula
- Mild Mint flavour
- Sangi's nano-hydroxyapatite (nano-mHAP)
- No fluoride
APAGARD Premio Extra Mint, Two Tubes
Two tubes of Premio in the stronger mint flavour.
- 3.7 oz, extra mint
- Set of 2
- Higher hydroxyapatite content than the standard type
- Pearl powder in the formula
- Xylitol among the sweeteners
APAGARD Smoker Care, Two Tubes
Two tubes of the smoker care paste, mild peppermint.
- 3.7oz(105g) set of two
- Set of 2
- Mild mint, peppermint
- 2023 version
- About 0.4 inch of paste per brushing
APAGARD Premio Double Mint, 100 g
A single 100 g tube of the Premio paste, double mint.
- 100 g, 3.5 oz
- Double Mint flavour
- Sangi's nano-hydroxyapatite (nano-mHAP)
- No fluoride
- Pack of 1
What sits inside every APAGARD tube

Nano-hydroxyapatite instead of fluoride
The active ingredient is Sangi's own nano-hydroxyapatite, nano-mHAP, first synthesized by the company in 1978. It is the building block of tooth enamel, and every tube in this range is fluoride-free.

Concentration marks the formula
M-Plus is the standard tube and the longest-selling of the range. Premio raises the share of the active ingredient, and Royal carries the highest content in the series, twice that of the standard tube.

Slow brushing is part of the method
The instruction on the tube asks for 1 to 1.5 cm of paste and three to five minutes of brushing, gently but meticulously, rinsing lightly afterwards so the residue stays in the mouth. It is a different routine from a thirty-second scrub.

A tube for each job
Stain removal has its own non-abrasive formula aimed at tobacco, tea, coffee and red wine. Renamel is built for home use after clinical cleaning, bleaching or orthodontic work, and adds xylitol, PEG and PVP.
What is in the paste and how to use it
One ingredient defines the range: nano-hydroxyapatite, the material teeth are largely made of, synthesized by Sangi in 1978 and sold under the name nano-mHAP. Royal adds liquid conchiolin, an ingredient from pearl, and keeps abrasives to a minimum or leaves them out altogether. Renamel brings xylitol, PEG and PVP alongside the maximum level of nano mHAP in the range.
None of these tubes contains fluoride, and the brand states it plainly on the pack. If a dentist has asked for a fluoride paste, this is not the range to switch to.
Brushing is the part people get wrong. Place a small amount, 1 to 1.5 cm, on the brush. Brush teeth and gums gently but meticulously for about 3-5 minutes, ideally after each meal, three times a day. Rinse lightly and spit out after brushing rather than washing everything away, so what remains keeps working. Renamel adds a second round: brush once, spit, apply more paste and brush again.
| Active ingredient | Nano-hydroxyapatite (nano-mHAP) by Sangi |
|---|---|
| Fluoride | None in any tube of the range |
| Sizes | 100, 105, 120, 125 and 135 g |
| Packs | Single tubes, packs of two and three |
| Flavours | Mild mint, double mint, extra mint |
| Brushing time | 3-5 minutes, ideally after each meal |

Formulas and pack sizes change by listing
The same formula is sold as one tube, two or three, and grams differ between them. Check which pack a listing covers.
Check the current tubesWhich tube suits which routine

Every day, for the whole family
M-Plus is the tube most households end up with: mild mint, 125 or 130 grams, and the formula that has been in the range longest. Buy it in twos or threes if more than one person brushes with it.

Coffee in the morning, wine in the evening
The stain-removal tubes are aimed at exactly that: marks from tobacco, tea, coffee and red wine, lifted by a non-abrasive formula rather than by scrubbing. Smoker Care covers the same ground in a two-tube set.

After the dentist's chair
Renamel is the home-care tube, made for the weeks after mechanical cleaning, bleaching or orthodontic work. It carries the maximum level of nano mHAP in the range and asks for the double brushing routine.

When you want the strongest formula
Royal holds the highest nano mHAP content in the series, twice that of the standard tube, with liquid conchiolin from pearl and almost no abrasives. It is the 135 gram tube at the top of the range.
About the APAGARD range
APAGARD is the toothpaste line built around nano-hydroxyapatite by Sangi, the Japanese company that first synthesized the material in 1978. The whole range runs on that one ingredient, and the tubes differ by how much of it they carry and what else is mixed in.
Five formulas cover the shelf. M-Plus is the everyday tube, Premio raises the concentration, Royal sits at the top of the series, Renamel is the home-care paste for the weeks after dental work, and the stain-removal tubes take on coffee, tea, wine and tobacco.
Sizes and packs matter as much as the formula here, because the same paste is sold as a single 100 gram tube or as three 125 gram ones. Decide on the formula first, then on how long you want it to last.
This catalogue lists the range from the outside. It is not the manufacturer's own shop.
Questions about these tubes
What is nano-hydroxyapatite and why is it here?
Do any of these contain fluoride?
How long should brushing take?
What separates M-Plus, Premio and Royal?
Which tube is for stains from coffee or smoking?
When is Renamel the right choice?
The formulas side by side
Concentration, size and what each tube is aimed at.
| APAGARD | Formula | Size | Flavour | Aimed at | Check price on Amazon |
|---|---|---|---|---|---|
| APAGARD M-Plus, single tube | Standard | 125 g | Mild mint | Everyday brushing | Check price on Amazon |
| M-Plus 130 g | Standard | 130 g | Mild mint | The largest single tube | Check price on Amazon |
| APAGARD Premio, 100 g | Higher | 100 g | Double mint | More active ingredient | Check price on Amazon |
| Premio, three tubes | Higher | 105 g × 3 | Mint | Stocking up | Check price on Amazon |
| APAGARD Royal, 135 g | Highest | 135 g | Mild mint | The top of the range | Check price on Amazon |
| Renamel home care | Maximum mHAP | 120 g | Mint | After dental work | Check price on Amazon |
| Smokin' stain removal | Standard | 100 g | Mild mint | Tobacco and coffee marks | Check price on Amazon |
Brush with Japanese nano-hydroxyapatite
APAGARD Premio, M-Plus, Smokin’ and Renamel toothpastes from Sangi. Check the formula, size and today’s price on Amazon.










